What is Dengue Virus?
Dengue Virus (DENV) is a mosquito-transmitted flavivirus with a single-stranded RNA genome of approximately 11 kb long and four different serotypes (DENV1-4). The clinical manifestations of dengue fever vary from mild fever to severe, potentially life-threatening illnesses such as dengue fever and dengue shock syndrome. Dengue NS1 rapid test device can diagnosis it at beginning.
Principle:
Dengue virus nonstructural protein 1 (NS1) is a 45 kDa multifunctional glycoprotein that plays an important role in viral replication, pathogenesis, and immune evasion. NS1 is expressed in the cytoplasm and can form dimers and hexamers, the latter of which can be secreted outside the cell. Glycosylation of NS1 is critical for its secretion and stability.
Symptom:
Symptoms of dengue fever can range from mild fever to
1) severe blood vessel leakage
2) bleeding tendencies
3) low platelets
The NS1 protein is associated with severe forms of dengue fever, and high levels of circulating NS1 are associated with the development of dengue hemorrhagic fever
Transmission route:
1) Mosquito-borne transmission: Dengue virus is mainly transmitted to humans through the bite of Aedes aegypti or Aedes albopictus infected with dengue virus.
2) Vertical transmission: Dengue virus infection in pregnant women may be transmitted to the fetus during pregnancy or delivery, which may lead to fetal death, low birth weight, premature birth and other problems.
3) Unconventional routes: Although rare, dengue virus can also be spread through blood-borne transmission in a laboratory or medical setting, organ transplants, or needle stick injuries. Additionally, there is evidence that sexual contact may also spread dengue virus
Prevention and control:
1) Vaccines: There are currently vaccines on the market against dengue fever, such as Dengvaxia, but they are only effective for first-time infections in people of a certain age. The new vaccine Q-DENGA has been approved in Brazil, but further research is needed to evaluate its effectiveness.
2) Antiviral treatment: There are currently no specific antiviral drugs approved for the treatment of dengue fever. However, some drugs such as celgosivir and minocycline are under investigation that provide protection by changing the structure and function of the NS1 protein.
NS1-targeted therapy: Research shows that using monoclonal antibodies against NS1 protects mice from fatal dengue virus infection.
3) Diagnosis: dengue NS1 rapid test device is an important means of diagnosing dengue fever, especially within the first 7 days of illness. A positive result confirms dengue virus infection but does not provide serotype information. Such as we can use dengue igg igm rapid test device, dengue NS1 rapid test device and dengue igg igm & NS1 rapid test device to comfirm it when we have some symptoms
4) Preventative measures: The best way to prevent dengue fever is to control mosquito populations and reduce mosquito breeding sites by using mosquito repellents, wearing long-sleeved clothing, and eliminating standing water.
5) Early recognition and treatment: Recognizing dengue symptoms early and seeking medical help is critical to preventing serious complications.
Through these methods, dengue fever can be effectively prevented and treated and its impact on public health reduced.