The updated agreement states that weak muscles, as opposed to a low total body mass, should be present before a diagnosis of likely sarcopenia is made. Uncertainty exists regarding the possibility of utilizing the modified creatinine index to identify individuals with likely sarcopenia as being at risk of adverse consequences (mCI). Researchers wanted to know if hemodialysis patients with high mCI scores had a higher risk of sarcopenia and sarcopenic mortality. In the cross-sectional study (n=346), univariate and multivariate logistic regression analysis was used to assess the relationship between mCI and sarcopenia. Using the Modified Quantitative Subjective Global Assessment (MQSGA), the nutritional status was evaluated.
This study evaluated the capability of the mCI value to identify likely sarcopenia using receiver operating characteristic (ROC) curve analysis. The appropriate thresholds were determined using Youden's method. In a longitudinal cohort analysis of an independent hemodialysis cohort (n=218), cox proportional regression models were used to assess the crude and adjusted hazard ratios and 95% confidence intervals (CIs) of death by mCI and MQSGA.The link between mCI and weak muscles remained significant in the cross-sectional analysis after potential confounding variables were taken into account. When predicting likely sarcopenia in men, the mCI had an area under the curve (AUC) of 0.804 (95% CI, 0.744-0.863; P 0.001), whereas in women, it had an AUC of 0.787 (95% CI, 0.711-0.864; P 0.001). Men's best mCI cutoff values were 21.07 mg/kg/d and women's were 19.57 mg/kg/d. Those with low mCI had a higher risk of passing away from any cause than those with high mCI, per the follow-up data (adjusted HR, 2.51; 95% CI, 1.16-5.41; P=0.019).
When the mCI was incorporated, the C-index for death prediction went up from 0.785 to 0.805 (P=0.026), and the net reclassification index was up by 38.6% (P=0.021), while the addition of MQSGA had no impact. Since the mCI evaluates muscular strength and survival, it is more reliable than the MQSGA at predicting mortality in hemodialysis patients. The predictive and prognostic usefulness of sarcopenia may be enhanced by the assessment of mCI.
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