Parkinson's is a condition where the patient's brain steadily deteriorates over the course of their lifetime. Slow movement, tremors, and stiff muscles are a few serious signs. Moreover, it may result in side effects include memory loss, sadness, anxiety, and sleeplessness. The condition is caused by fewer nerve cells in the brain's substantia nigra, which lowers levels of dopamine. Dopamine is essential for many bodily processes, including motivation, arousal, reinforcement, and reward, hence its lack can have negative effects, such Parkinson's disease (PD). There is no one method that makes a diagnosis. A neurologist makes the diagnosis of PD by reviewing your medical history, examining your symptoms, and performing both physical and neurological tests. A healthcare professional may ask for lab procedures, such as blood tests, MRIs, and imaging tests, to rule out other diseases. A diagnosis does not appear immediately. Healthcare professionals may suggest routine consultations with neurologists to assess your condition over time and establish if you have the disease or not. Although PD can be diagnosed in younger patients, the majority of people start to experience symptoms around the age of 50. In comparison to women, men are also more susceptible to the illness. According to the National Council on Aging, tremors, loss of smell, constipation, difficulty moving and sleeping, as well as small handwriting, are some early signs of Parkinson's disease (PD). It is known that modifications in the measurements of isomeric lipids, which vary in the placement of the double bond or the arrangement of the fatty acid chains, can be useful biomarkers for various diseases, such as type 2 diabetes and cancer. Lipids may be useful indicators for the disease given that they are altered in the plasma of PD patients.
What the research has found？
Dr. Blaine Roberts' research focuses on understanding Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis. He is an Associate Professor in the Departments of Biochemistry and Neurology at Emory University. Roberts went into detail about his research, which uses ion mobility mass spectrometry to identify disease-specific lipid isomers that can be used to determine an early diagnosis of Parkinson's disease, in his webinar titled "Discover Lipid Biomarkers for Parkinson's Disease Using MS," which was held on March 9. Early diagnosis of Parkinson's disease (PD) can be very beneficial since it can lead to early treatment with levodopa and carbidopa medications, which are more successful when given at an early stage. Even light exercise in the early stages of Parkinson's disease can help gradually reduce symptoms.
"Lipids could be a good source of biomarkers for PD," continues Roberts.Roberts' investigation into the potential use of lipids for future diagnostics continues.Finally, he says: "In conclusion, we verified the quantity of lipid alterations. We discovered this peculiar mismatch between the levels or changes in red blood cell lipids as contrasted to the changes in the plasma in some of the lipid alterations that individuals had previously seen in the literature. And that's a topic we want to investigate further."
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