According to research from both real-world and study contexts, high serum uric acid levels are linked to higher chances of all-cause and cardiovascular death in people with diabetes.
According to the US National Health and Nutrition Examination Study (NHANES), which covered 7101 persons with diabetes from 1999 to 2018, 1900 of them passed away, including 674 from cardiovascular diseases. Shuang Rong, PhD, of Wuhan University of Science and Technology in China, and colleagues reported in Diabetes Care that patients with the highest quintile of serum uric acid (more than 6.9 mg/mL) had a significant 28% and 41% increased risk for all-cause and cardiovascular mortality, respectively, compared with patients with the lowest quintile of serum uric acid (less than 4.4 mg/mL). In this nationally representative population, the risk for all-cause and cardiovascular death significantly rose by 7% and 10%, respectively, for every 1 mg/mL increase in blood uric acid. For demographics, food and lifestyle factors, cardiovascular risk factors, diabetes duration, medications, comorbid disorders, and kidney function, the researchers made adjustments to the model.
A separate meta-analysis of 13 observational cohort studies comprising 51,368 diabetic patients was carried out by the team of Dr. Rong. Among them, 1682 of the 5242 patients who passed away had cardiovascular illness. They found that the risk of death from all causes and cardiovascular disease considerably increased by 8% and 5% for every 1 mg/dL increase in blood uric acid. The researchers concluded that endothelial dysfunction, cardiometabolic disorders, and inflammation may be involved in the association they had seen between elevated mortality and blood uric acid levels.
“Clinical trials are needed to determine the potential effects of lowering levels of circulating uric acid medications on cardiovascular health.”
A weakness of the study was its inability to differentiate between type 1 and type 2 diabetes.
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